Keto. Explained. with Dr. Dominic D'Agostino
Dr. Dominic D’Agostino is a leading researcher into the therapeutic effects of the ketogenic diet. He is featured on Joe Rogan, Tim Ferriss, Impact Theory, TED, and dozens of other top media outlets. This is a wide-spanning conversation on high fat diets, time-restricted feeding, fasting, and even nutrition psychotherapy.
Who is Dr. Dominic D’Agostino?
Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology.
He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.
His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, and cancer. His current project is to identify cellular mechanisms of seizures from CNS oxygen toxicity and to develop mitigation strategies against it. His efforts have focused specifically on measuring brain EEG, neuronal excitability, reactive oxygen species (ROS) production and biomarkers of oxidative stress. The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. The shift in brain metabolism (from glucose to ketones) reduces neuronal hyperexcitability, oxidative stress and enhances brain energy metabolism.
Other areas of interest include researching drugs that target cancer-specific metabolic pathways. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations.
Resources
Episode Transcript
[3:44] Making two different diets work at home
[7:14] Life underwater for 10 days
[20:01] APOE4 and the Ketogenic diet’s effects on Alzheimer’s disease
[27:37] Effects of removing dairy and saturated fat on biomarkers
[33:21] The ketogenic diet and atherosclerosis
[37:40] How to build muscle in ketosis
[41:27] Taking a year off from weightlifting
[47:40] How to lose the benefits of intermittent fasting
[54:10] Dr. Dom’s opinion on one meal a day
[56:16] Should you schedule cheat meals?
[1:06:00] The importance of micronutrients
[1:08:05] The best keto snacks
[1:13:40] Adherence and ketosis
